Parabens inhibit hNaV 1.2 channels
نویسندگان
چکیده
منابع مشابه
Parabens in Breast Tumours
This issue of Journal of Applied Toxicology publishes the paper Concentrations of Parabens in Human Breast Tumours by Darbre et al. (2004), which reports that esters of p-hydroxybenzoic acid (parabens) can be detected in samples of tissue from human breast tumours. Breast tumour samples were supplied from 20 patients, in collaboration with the Edinburgh Breast Unit Research Group, and analysed ...
متن کاملParabens in Human Breast Tumours
P. D. Darbre,* A. Aljarrah, W. R. Miller, N. G. Coldham, M. J. Sauer and G. S. Pope 1 Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK 2 The Edinburgh Breast Unit Research Group, Paderewski Building, Western General Hospital, Edinburgh EH4 2XU, UK 3 Department of Bacterial Diseases, Veterinary Laboratories Agency, Weybri...
متن کاملProstaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness.
Regulation of the factors governing IL-12R expression and IL-12 responsiveness has been shown to be important in the generation and stability of Th1- and Th2-type responses. In this regard, cytokines have been shown to have a prominent role in regulating IL-12R expression. In this study, the role that PGE2 and dexamethasone (DXM) have in regulating IL-12R expression was evaluated. Addition of P...
متن کاملKetamine and propofol differentially inhibit human neuronal K(+) channels.
BACKGROUND AND OBJECTIVE Interaction of intravenous anaesthetic agents with voltage-dependent potassium channels significantly correlates with clinical concentrations. If potassium channels were to play an important part in anaesthesia, one might expect different effects at the molecular level of those anaesthetics that show different clinical effects. Our aim was to analyse the interaction of ...
متن کاملIntracellular ATP does not inhibit Slo2.1 K+ channels
Under normal physiological conditions, the open probability of Slo2.1 K(+) channels is low. Elevation of cytosolic [Na(+)] and [Cl(-)] caused by ischemia or rapid electrical pacing of cells increases the open probability of Slo2.1 channels and the resulting outward current can stabilize the resting state of cells. Initial characterization of heterologously expressed human Slo2.1 indicated that ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2020
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2020.110250